Description

Amonafide-D6 is a deuterated analog of the investigational antineoplastic agent Amonafide, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic research, providing a critical tool for method validation and data integrity. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and analysis of novel chemotherapeutic agents.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of Amonafide in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studies investigating the absorption, distribution, metabolism, and excretion (ADME) profile of Amonafide in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to establish and validate robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based assays.
• Preclinical Toxicology Studies: Employed in the accurate measurement of drug concentrations to establish exposure-toxicity relationships.
• Reference Material for Quality Control: Acts as a certified reference material to ensure the consistency and accuracy of analytical results across different batches and laboratories.

Basic Information

Item	Detail
Product Name	Amonafide-D6
CAS No.	1217039-92-3
Molecular Formula	C₁₆H₁₂D₆N₄O₂
Molecular Weight	292.36 g/mol
Synonyms	5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione-d6; 1,8-Naphthalimide-d6 derivative; L-Alanamide, N-[2-(dimethylamino)ethyl]-1,8-naphthalimide-d6; Deuterated Amonafide; Amonafide Internal Standard; Amonafide-d6 (hexadeuterated)
EINECS	Contact for details

Quality Control

Every batch of Amonafide-D6 is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to guarantee compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with each shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.