Description

Ethyl 3-Amino-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block characterized by its benzothiophene core, amino group, and trifluoromethyl substituent. This compound is specifically engineered to serve as a critical intermediate in the synthesis of advanced molecules, offering significant advantages in modulating the physicochemical and biological properties of target compounds. It is primarily sought after by research and development teams within the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas like kinase inhibitors, anti-cancer agents, and central nervous system (CNS) therapeutics, where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the benzothiophene scaffold for bioactivity.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system and electron-donating/withdrawing groups.
• Chemical Biology Probe Development: Employed in creating fluorescent tags or molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Item	Detail
Product Name	Ethyl 3-Amino-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate
CAS No.	1217018-83-1
Molecular Formula	C12H10F3NO2S
Molecular Weight	289.27 g/mol
Synonyms	3-Amino-5-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid ethyl ester; Ethyl 3-amino-5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 5-(Trifluoromethyl)-3-aminobenzo[b]thiophene-2-carboxylic acid ethyl ester; 1-Benzothiophene-2-carboxylic acid, 3-amino-5-(trifluoromethyl)-, ethyl ester; ATFBEC; 1217018-83-1
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-Amino-5-(Trifluoromethyl)-1-Benzothiophene-2-Carboxylate is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and reliability for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.