Description

n-Acetyl Amonafide-D6 is a deuterated analog of the topoisomerase II inhibitor amonafide, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and precision in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analytical research for cancer therapeutics.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of amonafide and its metabolites in biological matrices.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies during preclinical and clinical development stages.
• Critical for conducting bioequivalence and bioavailability studies of amonafide-based formulations.
• Enables high-fidelity analytical method development and validation in compliance with FDA and ICH guidelines.
• Supports metabolite identification and profiling research in oncology drug discovery.
• Used in quality control laboratories for reference standard preparation.

Basic Information

Product Name	n-Acetyl Amonafide-D6
CAS No.	1217018-31-9
Molecular Formula	C₂₀H₁₃D₆N₃O₂
Molecular Weight	~335.40 g/mol
Synonyms	1-N-Acetylamonafide-D6; 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, N-Acetyl-, hexadeuterated; Deuterated N-Acetyl Amonafide; Amonafide-d6 Acetamide; [D6]-N-Acetyl Amonafide; Internal Standard for Amonafide LC-MS; Stable Isotope-Labeled Amonafide Derivative
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Amonafide-D6 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and impurity profile is provided with each shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D6)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.