Description

n-Benzyloxycarbonyl-4-(4-Chlorophenyl-D4)-4-Piperidinol is a deuterated piperidine derivative, a high-value building block designed for advanced pharmaceutical research and development. Its core value lies in its role as a labeled intermediate, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR analysis. This compound is essential for medicinal chemists and researchers in the pharmaceutical industry working on the synthesis of novel drug candidates, particularly within the central nervous system (CNS) and receptor modulator fields.

Application

• Deuterated Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) to study drug metabolism and stability.
• Metabolic Tracing Studies: Used in the development of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) to achieve accurate quantitative bioanalysis.
• Drug Discovery & Development: A key synthon in medicinal chemistry programs targeting neurological disorders, pain management, and psychiatric conditions.
• Isotope-Labeled Probe Synthesis: Enables the creation of molecular probes for investigating biological pathways and receptor binding mechanisms.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale production of deuterated drugs.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) settings for cutting-edge pharmacological research.

Basic Information

Product Name	n-Benzyloxycarbonyl-4-(4-Chlorophenyl-D4)-4-Piperidinol
CAS No.	1216929-70-2
Molecular Formula	C19H15D4ClNO3
Molecular Weight	348.85 g/mol (for deuterated form)
Synonyms	Z-4-(4-Chlorophenyl-d4)-4-hydroxypiperidine; 1-[(Benzyloxy)carbonyl]-4-(4-chlorophenyl-2,3,5,6-d4)-4-piperidinol; 4-(4-Chlorophenyl-d4)-4-hydroxy-1-piperidinecarboxylic acid benzyl ester; 4-Hydroxy-4-(4-chlorophenyl-d4)-1-piperidinecarboxylic acid benzyl ester; N-Cbz-4-(4-Chlorophenyl-d4)-4-piperidinol; 1-N-Carbobenzoxy-4-(4-chlorophenyl-d4)-4-piperidinol; Deuterated Cbz-protected 4-(4-chlorophenyl)-4-piperidinol.
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonyl-4-(4-Chlorophenyl-D4)-4-Piperidinol is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic enrichment (D-content by NMR/MS), and identity confirmation. We adhere to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require desiccant. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.