Description

2,3-Dihydro-5-Benzofuranacetic Acid-D2 is a deuterated derivative of a key benzofuran acetic acid scaffold, where specific hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for enhancing metabolic stability and providing a non-radioactive tracer in pharmacokinetic and drug metabolism studies. It is an essential building block and analytical standard for pharmaceutical R&D, particularly in the development of deuterated drugs and advanced mass spectrometry applications.

Application

• Deuterated Drug Development: Serves as a crucial intermediate for synthesizing deuterium-labeled active pharmaceutical ingredients (APIs) to improve metabolic profiles.
• Metabolic Research & Pharmacokinetics (PK/PD): Used as an internal standard in LC-MS/MS and GC-MS for the accurate quantification of parent compounds and metabolites in biological matrices.
• Mechanistic Studies: Employed to investigate metabolic pathways and isotope effects, helping to elucidate drug mechanisms of action.
• Chemical Reference Standard: Provides a high-purity certified standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Organic Synthesis Intermediate: Acts as a specialized building block for synthesizing novel, isotopically labeled compounds for research.

Basic Information

Product Name	2,3-Dihydro-5-Benzofuranacetic Acid-D2
CAS No.	1216878-16-8
Molecular Formula	C₁₀H₈D₂O₃
Molecular Weight	180.20 g/mol (approx.)
Synonyms	5-Benzofuranacetic-2,2-d2 acid, 2,3-dihydro-; 2-(2,3-Dihydro-5-benzofuranyl)acetic-2,2-d2 acid; Deuterated Dihydrobenzofuran Acetic Acid; [2,2-²H₂]-2,3-Dihydro-5-benzofuranacetic acid; 2,3-Dihydro-5-benzofuranylacetic acid-d2; 5-(Carboxymethyl)-2,3-dihydrobenzofuran-2,2-d2
EINECS	Contact for details

Quality Control

Every batch of 2,3-Dihydro-5-Benzofuranacetic Acid-D2 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, deuterium enrichment (D-content) by NMR or MS, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.