Description

n-[4-(4-Fluorophenyl)-5-Formyl-6-(1,1,1,3,3,3-Hexadeuteriopropan-2-Yl)Pyrimidin-2-Yl]-n-Methylmethanesulfonamide is a high-purity, deuterated pyrimidine derivative designed for advanced research and development. This compound is a critical intermediate or reference standard in the synthesis of novel pharmaceutical agents, particularly in the fields of oncology and metabolic disease. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, process chemistry, and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of deuterated drug candidates for improved metabolic stability and pharmacokinetics.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in active pharmaceutical ingredient (API) manufacturing.
• Metabolic Studies: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate bioanalysis and pharmacokinetic studies.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to explore the impact of deuteration on biological activity.
• Process Chemistry: Used in route scouting and optimization for the scalable production of target molecules.
• Isotope Labeling: Provides a deuterium-labeled probe for mechanistic studies in chemical and biochemical reactions.

Basic Information

Product Name	n-[4-(4-Fluorophenyl)-5-Formyl-6-(1,1,1,3,3,3-Hexadeuteriopropan-2-Yl)Pyrimidin-2-Yl]-n-Methylmethanesulfonamide
CAS No.	1216862-95-1
Molecular Formula	C22H21D6FN3O3S
Molecular Weight	453.55 g/mol
Synonyms	Deuterated Pyrimidine Sulfonamide Intermediate; 4-(4-Fluorophenyl)-5-formyl-6-((1,1,1,3,3,3-hexadeuterio-2-propanyl))-N-methyl-2-pyrimidinesulfonamide; N-Methyl-N-[4-(4-fluorophenyl)-5-formyl-6-[(1,1,1,3,3,3-hexadeuterio)propan-2-yl]pyrimidin-2-yl]methanesulfonamide; [D6]-Labeled Pyrimidine Sulfonamide; CAS 1216862-95-1
EINECS	Contact for details

Quality Control

Every batch of this deuterated intermediate is produced and tested under a strict quality management system. We provide comprehensive analytical data to support your regulatory and research requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chemical purity, isotopic enrichment, and impurity profile as determined by advanced techniques like HPLC, NMR, and LC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as argon or nitrogen in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.