Description

Doxylamine-D5 Succinate CAS NO 1216840-94-6 is a deuterated internal standard of the antihistamine doxylamine succinate, where five hydrogen atoms are replaced with deuterium. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors who require precise measurement of doxylamine in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of doxylamine in pharmacokinetic, pharmacodynamic, and toxicokinetic studies using LC-MS/MS or GC-MS.
• Pharmaceutical R&D: Used in method development and validation for drug metabolism and disposition studies of doxylamine-containing formulations.
• Forensic and Clinical Toxicology: Enables accurate measurement of doxylamine levels in blood, plasma, or urine for overdose cases, compliance monitoring, or post-mortem investigations.
• Reference Standard Manufacturing: Acts as a primary standard for the calibration and qualification of analytical methods and the certification of commercial reference materials.
• Regulatory Submissions: Supports data packages submitted to regulatory bodies (e.g., FDA, EMA) by providing validated analytical methods with appropriate internal standards.

Basic Information

Product Name	Doxylamine-D5 Succinate
CAS No.	1216840-94-6
Molecular Formula	C17H17D5N2O • C4H6O4
Molecular Weight	388.48 g/mol (approx.)
Synonyms	Doxylamine-d5 Succinate; 2-[1-Phenyl-1-(2-pyridyl)ethoxy]-N,N-dimethylethanamine-d5 Succinate; Doxylamine (phenyl-d5) Succinate; Doxylamine-d5 Hydrogen Succinate; N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine-d5 Succinate; Deuterated Doxylamine Succinate; Doxylamine Internal Standard; CAS 1216840-94-6
EINECS	Contact for details

Quality Control

Every batch of Doxylamine-D5 Succinate is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes assay by HPLC, determination of isotopic enrichment by mass spectrometry, and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium, D)	≥ 98 atom % D
Isotopic Enrichment (by MS)	≥ 95% (D5)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.