Description

n-Carbamoyl-2-Fluoro-2-Alanine-13C3 is a stable isotope-labeled analog of a fluorinated alanine derivative, specifically enriched with carbon-13 at three positions. This compound is of critical importance as a high-value building block and internal standard in advanced pharmaceutical research and development. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis and metabolic studies of novel fluorinated drug candidates, particularly in areas like oncology and neurology where precise tracing is essential.

Application

• Isotopic Internal Standard for LC-MS/MS: Used for the accurate quantification of its non-labeled counterpart or related metabolites in complex biological matrices during pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Tracer in Metabolic Pathway Analysis: Employed in biomedical research to elucidate metabolic pathways and mechanisms of action for fluorinated amino acid-based therapeutics using techniques like NMR or mass spectrometry.
• Building Block for Labeled Peptides/Proteins: Serves as a specialized precursor for the synthesis of carbon-13 labeled peptides or modified proteins for structural biology and biophysical studies.
• Reference Material in Analytical Method Development: Essential for developing and validating highly sensitive and specific bioanalytical methods in compliance with GLP and GMP guidelines.
• Precursor for PET Tracer Development: While containing stable 13C, its core structure is relevant for research into potential positron emission tomography (PET) imaging agents when labeled with fluorine-18.

Basic Information

Item	Detail
Product Name	n-Carbamoyl-2-Fluoro-2-Alanine-13C3
CAS No.	1216798-07-0
Molecular Formula	C413C3H7FN2O3
Molecular Weight	~151.1 g/mol (for 13C3 labeled form)
Synonyms	2-Fluoro-2-(aminocarbonylamino)propanoic acid-13C3; (2R/S)-2-Fluoro-2-[(aminocarbonyl)amino]propanoic acid-13C3; 2-Fluoro-2-(carbamoylamino)propanoic acid-13C3; 13C3-Labeled 2-Fluoro-2-ureidopropionic acid; Fluorofexoramide impurity/intermediate-13C3; Ureidofluoroalanine-13C3; Alanine, 2-fluoro-2-ureido-, 13C3-labeled
EINECS	Contact for details

Quality Control

Every batch of n-Carbamoyl-2-Fluoro-2-Alanine-13C3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of research and regulatory submission support. Comprehensive testing includes isotopic enrichment assay, chiral purity (where applicable), and identification of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.