Description

Nabumetone-D3 is a deuterated isotopologue of the non-steroidal anti-inflammatory drug (NSAID) Nabumetone, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is a critical tool in modern pharmaceutical research and development, enabling precise and reliable analytical studies. It is primarily utilized by researchers and analytical laboratories in the pharmaceutical and contract research organization (CRO) sectors for applications such as quantitative mass spectrometry and metabolic pathway investigation.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of Nabumetone and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to trace and understand the metabolic fate of Nabumetone.
• Bioanalytical Method Development: Essential for developing and validating robust, high-sensitivity analytical methods for Nabumetone in compliance with regulatory guidelines (e.g., FDA, EMA).
• Stable Isotope Dilution Assays: Employed in isotope dilution techniques to achieve high precision and accuracy in quantitative analysis, minimizing matrix effects.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of potential impurities or degradation products during drug substance and product development.
• Clinical Research: Supports pharmacokinetic and bioequivalence studies in clinical trials, ensuring reliable data for regulatory submissions.

Basic Information

Product Name	Nabumetone-D3
CAS No.	1216770-08-9
Molecular Formula	C15H15D3O2
Molecular Weight	231.31 g/mol (approx.)
Synonyms	4-(6-Methoxy-2-naphthalenyl)-2-butanone-d3; Nabumetone (phenyl-d3); Nabumetone-d3 (hexadeuterated); Relafen-d3; 4-(6-Methoxynaphthalen-2-yl)butan-2-one-d3; Deuterated Nabumetone; Nabumetone (methyl-d3); [2H3]-Nabumetone
EINECS	Contact for details

Quality Control

Our Nabumetone-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is analyzed using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.