Description

Buspirone-D8 Hcl (Butyl-D8) is a deuterium-labeled analog of the anxiolytic pharmaceutical compound buspirone hydrochloride, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolism studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and forensic toxicology sectors who require precise measurement of buspirone and its metabolites.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of buspirone.
• Critical component in pharmacokinetic and bioanalytical studies to determine drug concentration in biological matrices like plasma, serum, and urine.
• Essential for drug metabolism and disposition (DMPK) research, aiding in the identification and quantification of metabolites.
• Used in pharmaceutical quality control and stability testing to ensure product potency and purity.
• Valuable reference material in forensic and clinical toxicology for the accurate assessment of buspirone exposure.
• Supports method development and validation in analytical laboratories, enhancing method robustness.
• Applicable in environmental monitoring studies researching the fate of pharmaceutical compounds.

Basic Information

Item	Detail
Product Name	Buspirone-D8 Hcl (Butyl-D8)
CAS No.	1216761-39-5
Molecular Formula	C21H23D8N5O2•HCl
Molecular Weight	421.99 g/mol
Synonyms	Buspirone-d8 Hydrochloride; 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl-d8]-8-azaspiro[4.5]decane-7,9-dione Hydrochloride; Butyl-d8 Buspirone HCl; Deuterated Buspirone HCl; Buspirone (Butyl-d8) Hydrochloride; Buspirone-d8 HCl; 1216761-39-5 (CAS); Azapirone-d8 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Buspirone-D8 Hcl (Butyl-D8) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with the high-purity standards required for analytical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.