Description

Mefenamic Acid D4 CAS NO 1216745-79-7 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) mefenamic acid, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research, bioanalytical laboratories, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic (DMPK) studies, and clinical trial analysis.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise analysis of mefenamic acid in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of mefenamic acid.
• Bioanalytical Method Development and Validation: Critical for developing and validating robust, GLP-compliant analytical methods for therapeutic drug monitoring and clinical research.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of metabolites and related substances during drug development and quality control.
• Clinical and Pre-clinical Research: Supports pharmacokinetic studies in both animal models and human clinical trials to determine drug concentration levels accurately.
• Forensic and Anti-Doping Analysis: Employed in specialized testing laboratories for the accurate detection and quantification of mefenamic acid.

Basic Information

Product Name	Mefenamic Acid D4
CAS No.	1216745-79-7
Molecular Formula	C15H11D4NO2
Molecular Weight	245.31 g/mol
Synonyms	2-[(2,3-Dimethylphenyl)amino]benzoic-3,4,5,6-d4 Acid; Deuteronated Mefenamic Acid; Mefenamic Acid-d4; Ponstel-d4; Mefenamic Acid (phenyl-d4); [phenyl-d4]-Mefenamic Acid; N-(2,3-Dimethylphenyl)anthranilic Acid-d4
EINECS	Contact for details

Quality Control

Our Mefenamic Acid D4 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, meeting the exacting requirements of analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (by 1H-NMR or MS), chemical purity (by HPLC), and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance in sensitive mass spectrometry applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.