Description

Nicotinuric Acid-D4 is a stable isotope-labeled analog of nicotinuric acid, where four hydrogen atoms are replaced by deuterium. This high-purity internal standard is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors requiring precise metabolic profiling and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of nicotinuric acid and related metabolites.
• Metabolomics Research: Enables accurate tracking and quantification of tryptophan-nicotinamide metabolic pathways in disease state investigations.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to determine the pharmacokinetic profile of drug candidates.
• Biomarker Validation: Supports the development and validation of clinical biomarkers related to NAD+ metabolism and liver function.
• Nutritional Science Studies: Facilitates precise measurement of niacin (Vitamin B3) metabolism and status in nutritional intervention research.
• Quality Control in Pharmaceutical Manufacturing: Serves as a critical reference material for the QC of APIs and formulations where nicotinuric acid is a metabolite or related compound.

Basic Information

Product Name	Nicotinuric Acid-D4
CAS No.	1216737-36-8
Molecular Formula	C8D4H4N2O3
Molecular Weight	184.17 g/mol
Synonyms	N-(2,4,5,6-Tetradeuteriopyridine-3-carbonyl)glycine; Deuterated Nicotinuric Acid; Nicotinuric Acid (phenyl-D4); N-(Pyridine-3-carbonyl)glycine-D4; 3-Carbamoylpyridineacetic Acid-D4; Niacinuric Acid-D4; 3-Pyridineglyoxylic Acid Ureide-D4
EINECS	Contact for details

Quality Control

Our Nicotinuric Acid-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment (typically ≥98 atom % D) and chemical purity (typically ≥95% by HPLC). A Certificate of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Isotopic Purity (Atom % D)	≥98%
Chemical Purity (HPLC)	≥95%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.