Description

Harmine-D3 is a deuterated analog of the naturally occurring β-carboline alkaloid, harmine, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and life science sectors who require precise quantification of harmine in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of harmine in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Research: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of harmine and related compounds.
• Pharmaceutical Development: Enables precise drug metabolism and pharmacokinetics (DMPK) analysis during the development of harmine-based therapeutics.
• Forensic and Clinical Toxicology: Provides a reliable standard for the confirmatory analysis of harmine in forensic and clinical samples.
• Biochemical Assay Development: Utilized in the development and validation of high-sensitivity assays for β-carboline alkaloids.
• Reference Material: Acts as a certified reference material (CRM) for instrument calibration and method validation in analytical laboratories.

Basic Information

Product Name	Harmine-D3
CAS No.	1216704-96-9
Molecular Formula	C13H9D3N2O
Molecular Weight	215.25 g/mol
Synonyms	7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole-d3; 1-Methyl-7-methoxy-β-carboline-d3; Harmine (methyl-d3); Harmine-d3 (internal standard); Deuterated Harmine; [2H3]-Harmine; 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole-d3
EINECS	Contact for details

Quality Control

Our Harmine-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of interferents. We adhere to cGMP principles for the production of reference standards, ensuring traceability, consistency, and compliance with global regulatory expectations for analytical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.