Description

4-Methoxy-2,3,6-Trimethylbenzaldehyde-D3 is a deuterated aromatic aldehyde, specifically a trideuterated derivative of 4-Methoxy-2,3,6-Trimethylbenzaldehyde. This compound is a high-value stable isotope-labeled intermediate, essential for creating internal standards used in advanced analytical techniques like LC-MS/MS and GC-MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of diagnostic kits for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical, isotopically labeled internal standard for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetic (DMPK) studies to track and measure parent drugs and metabolites with high precision.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific LC-MS/MS or GC-MS assays for regulatory submissions.
• Clinical Research & Diagnostics: Employed in the manufacturing of diagnostic assays and kits for therapeutic drug monitoring (TDM) and clinical trial sample analysis.
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of drug-derived metabolites in in vitro and in vivo studies.
• Chemical Synthesis Intermediate: Acts as a specialized building block for synthesizing more complex deuterated molecules for research purposes.

Basic Information

Product Name	4-Methoxy-2,3,6-Trimethylbenzaldehyde-D3
CAS No.	1216683-89-4
Molecular Formula	C12H12D3O2
Molecular Weight	195.27 g/mol
Synonyms	2,3,6-Trimethyl-4-methoxybenzaldehyde-D3; 4-Methoxy-2,3,6-trimethylbenzaldehyde-α,α,α-d3; 4-Methoxy-2,3,6-trimethylbenzaldehyde (trideuterated); 4-Methoxy-2,3,6-trimethylbenzaldehyde-d3; Deuterated 4-Methoxy-2,3,6-Trimethylbenzaldehyde; 4-Methoxy-2,3,6-trimethylbenzaldehyde (methyl-d3); (2,3,6-Trimethyl-4-methoxyphenyl)formaldehyde-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control to ensure high isotopic purity and chemical purity, meeting the exacting standards required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and MS. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (atom % D), chemical purity, and analytical data. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.