Description

Miconazole-D5 CAS NO 1216653-50-7 is a deuterium-labeled analog of the widely used antifungal agent Miconazole, serving as a critical internal standard for precise quantitative analysis. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in bioanalytical and pharmacokinetic studies, particularly in drug development and clinical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring definitive methods for drug quantification.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the accurate quantification of Miconazole and its metabolites in biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical trials.
• Drug Metabolism Research (DMPK): Facilitates the identification and measurement of metabolite formation, supporting drug metabolism and pharmacokinetics (DMPK) investigations.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for confirmatory testing in forensic toxicology and sports anti-doping controls.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for Miconazole-based drug products.

Basic Information

Product Name	Miconazole-D5
CAS No.	1216653-50-7
Molecular Formula	C18H9D5Cl4N2O
Molecular Weight	421.14 g/mol (approximate)
Synonyms	1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole-d5; Miconazole-d5; Deuterated Miconazole; Miconazole (phenyl-d5); Miconazole Internal Standard; (RS)-1-(2-(2,4-Dichlorophenyl)-2-((2,4-dichlorobenzyl)oxy)ethyl)-1H-imidazole-d5
EINECS	Contact for details

Quality Control

Our Miconazole-D5 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.