Description

Norfloxacin-D8 is a deuterated analog of the broad-spectrum fluoroquinolone antibiotic Norfloxacin, where eight hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is a critical internal standard for ensuring the accuracy and reliability of quantitative mass spectrometry analysis. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and analytical chemistry sectors who require precise quantification of Norfloxacin in complex biological and environmental matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for pharmacokinetic, bioequivalence, and metabolism studies.
• Pharmaceutical Research & Development: Used in the development and validation of analytical methods for Norfloxacin and related fluoroquinolones in drug substance and product testing.
• Clinical and Forensic Toxicology: Enables precise measurement of Norfloxacin concentrations in human and animal plasma, serum, urine, and tissues for therapeutic drug monitoring and forensic analysis.
• Environmental Analysis: Serves as a recovery standard in the quantification of antibiotic residues in water, soil, and agricultural samples.
• Metabolite Identification Studies: Aids in the identification and quantification of Norfloxacin metabolites in in vitro and in vivo studies due to its isotopic signature.
• Quality Control & Assurance: Critical for ensuring the accuracy of analytical results in GMP and GLP-compliant laboratories.

Basic Information

Product Name	Norfloxacin-D8
CAS No.	1216601-32-9
Molecular Formula	C16H10D8FN3O3
Molecular Weight	327.34 g/mol
Synonyms	1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid-d8; 1-Ethyl-6-fluoro-7-(piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8; Norfloxacin (ethyl-d5, piperazine-d3); Norfloxacin-d8; [ethyl-d5, piperazine-2,2,3,3,5,5,6,6-d8]-Norfloxacin
EINECS	Contact for details

Quality Control

Our Norfloxacin-D8 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, purity, and isotopic abundance. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.