Description

(2Rs,3Rs)-1-Amino-3-(2-Ethoxy-D5-Phenoxy)-2-Hydroxy-3-Phenylpropane, Methanesulfonate Salt is a high-purity, deuterated chiral compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its utility as a stable isotope-labeled intermediate or reference standard for pharmacokinetic, metabolic, and bioanalytical studies. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing novel active pharmaceutical ingredients (APIs) where precise metabolic tracing is required.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of the parent drug or its metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Utilized in drug discovery and development for mass spectrometry-based studies to elucidate metabolic pathways and identify metabolites due to its deuterium labeling.
• Internal Standard for Bioanalysis: Employed in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods as a stable isotope-labeled internal standard to ensure accurate and precise analytical results.
• Chiral Intermediate Synthesis: Acts as a key chiral building block for the synthesis of more complex, stereochemically defined pharmaceutical compounds.
• Pharmacokinetic (PK) Studies: Used in preclinical and clinical research to accurately measure drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Impurity Profiling: Aids in the identification and control of process-related impurities and degradants during API manufacturing and quality control.

Basic Information

Product Name	(2Rs,3Rs)-1-Amino-3-(2-Ethoxy-D5-Phenoxy)-2-Hydroxy-3-Phenylpropane, Methanesulfonate Salt
CAS No.	1216592-04-9
Molecular Formula	C18H18D5NO5S
Molecular Weight	~376.49 g/mol
Synonyms	(2R,3R)-1-Amino-3-[2-(ethoxy-d5)phenoxy]-2-hydroxy-3-phenylpropane methanesulfonate; Deuterated Etilefrine Mesylate Derivative; (2R,3R)-1-Amino-3-(2-ethoxy-d5-phenoxy)-2-hydroxy-3-phenylpropane methanesulfonate; (2R,3R)-3-(2-Ethoxy-d5-phenoxy)-1-amino-2-hydroxy-3-phenylpropane methanesulfonate; Etilefrine-d5 Methanesulfonate Salt (stereospecific); 1-Amino-3-(2-ethoxy-d5-phenoxy)-2-hydroxy-3-phenylpropane methanesulfonate (2R,3R)-isomer; CAS 1216592-04-9
EINECS	Contact for details

Quality Control

Our (2Rs,3Rs)-1-Amino-3-(2-Ethoxy-D5-Phenoxy)-2-Hydroxy-3-Phenylpropane, Methanesulfonate Salt is manufactured under strict quality systems to ensure high chemical and isotopic purity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), chiral purity, isotopic enrichment, and related substances. We adhere to cGMP principles where applicable to support its use in regulated pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. The compound is hygroscopic (moisture-sensitive); therefore, the container should be kept in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3R)-isomer
Isotopic Enrichment (MS)	≥ 98 atom % D (at designated positions)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.