Description

1,3,4,5,6,7,8-Heptadeuterio-9H-Pyrido[3,4-B]Indole is a high-purity deuterated analog of the β-carboline alkaloid, norharmane, specifically designed for advanced research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and reducing matrix effects in complex sample analyses. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in metabolomics, pharmacokinetic studies, and neurochemical research.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of norharmane and related β-carbolines in biological matrices such as plasma, urine, and tissue homogenates.
• Metabolomics and Biomarker Discovery: Used in stable isotope dilution assays to identify and measure endogenous metabolites with high precision.
• Pharmacokinetic and Drug Metabolism Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) for novel therapeutic agents.
• Neurochemical Research: Supports investigations into the role of β-carbolines in neurological processes and their interactions with receptors like benzodiazepine and monoamine oxidase.
• Forensic and Clinical Toxicology: Aids in the sensitive detection and confirmation of alkaloids and related compounds in forensic samples.
• Chemical Reference Material: Serves as a certified standard for calibrating analytical instruments and validating methods in quality control laboratories.
• Isotope Labeling Studies: Facilitates mechanistic studies in organic chemistry and biochemistry where deuterium tracing is required.

Basic Information

Product Name	1,3,4,5,6,7,8-Heptadeuterio-9H-Pyrido[3,4-B]Indole
CAS No.	1216503-21-7
Molecular Formula	C11D7H2N2
Molecular Weight	~177.23 g/mol
Synonyms	Norharmane-d7; 9H-Pyrido[3,4-b]indole-d7; β-Carboline-d7; 1,3,4,5,6,7,8-Heptadeuterionorharmane; NSC 81925-d7; 9H-β-Carboline-d7; Deuterated Norharmane; Perdeuterated Norharmane (partial)
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured under strict quality management systems. We guarantee high chemical and isotopic purity through rigorous analytical controls, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment (D-incorporation), and solvent residue levels to ensure compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic nature, the product should be handled in a moisture-controlled environment (e.g., desiccator or glovebox) for long-term stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.