Description

Homogentisic Acid-13C6 is a stable isotope-labeled analog of homogentisic acid, where six carbon atoms are replaced with the 13C isotope. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by research institutions, pharmaceutical companies, and CROs engaged in metabolic disorder research, particularly in studies of alkaptonuria, and for advanced LC-MS/MS method development.

Application

• Quantitative Mass Spectrometry Internal Standard: Serves as a critical reference standard for the precise quantification of endogenous homogentisic acid in biological matrices via LC-MS/MS.
• Metabolic Pathway Research: Used in tracer studies to investigate the tyrosine degradation pathway and the pathophysiology of alkaptonuria.
• Biomarker Analysis & Validation: Enables accurate measurement of homogentisic acid as a diagnostic biomarker in clinical and preclinical studies.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies for therapeutics targeting metabolic diseases.
• Quality Control in Clinical Laboratories: Ensures the accuracy and reproducibility of diagnostic assays for metabolic disorders.
• Stable Isotope Dilution Assays (SIDA): A key component in high-precision analytical techniques for absolute quantification.

Basic Information

Product Name	Homogentisic Acid-13C6
CAS No.	1216468-48-2
Molecular Formula	13C6H8O4
Molecular Weight	~174.10 g/mol
Synonyms	2,5-Dihydroxyphenylacetic acid-13C6; Alkapton-13C6; 13C6-HGA; (2,5-Dihydroxyphenyl)acetic acid-13C6; Homogentisate-13C6; 13C6-Labeled Homogentisic Acid; 13C6-2,5-DHPA; Stable Isotope-Labeled HGA
EINECS	Contact for details

Quality Control

Every batch of Homogentisic Acid-13C6 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including NMR and MS analysis for isotopic enrichment and HPLC for chemical purity, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. The material is light-sensitive (store away from light). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment (MS)	≥ 99% (M+6)
Chemical Purity (HPLC)	≥ 98%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.