Description

5-Acetylamino-6-Formylamino-3-Methyl-D3-Uracil is a high-purity, deuterated uracil derivative, specifically designed for advanced research and development applications. This compound serves as a critical stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic researchers focused on nucleoside chemistry, antiviral drug development, and mass spectrometry-based biomarker analysis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analogs and antiviral compounds.
• Stable Isotope Labeling: Used as an internal standard (D3-labeled) in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification in bioanalytical studies.
• Metabolic Pathway Research: Enables the tracing of uracil and related nucleoside metabolic pathways in biochemical and pharmacological research.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Chemical Biology Probes: Used in the development of probes for studying enzyme mechanisms involving uracil metabolism.
• Academic & Contract Research: Fundamental research in organic synthesis, medicinal chemistry, and isotope chemistry at universities and CROs.

Basic Information

Product Name	5-Acetylamino-6-Formylamino-3-Methyl-D3-Uracil
CAS No.	1216442-68-0
Molecular Formula	C8H8D3N3O4
Molecular Weight	214.19 g/mol
Synonyms	3-Methyl-5-acetylamino-6-formylamino-uracil-d3; 5-Acetamido-6-formamido-3-methyluracil-d3; 5-(Acetylamino)-6-(formylamino)-3-methyl-2,4(1H,3H)-pyrimidinedione-d3; Deuterated 5-Acetylamino-6-formylamino-3-methyluracil; D3-Labeled 5-AAF-3-MU; 5-AAF-3-MU-d3; 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione-d3 derivative (Acetylamino, Formylamino, Methyl substituted)
EINECS	Contact for details

Quality Control

Our 5-Acetylamino-6-Formylamino-3-Methyl-D3-Uracil is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity and NMR/MS for isotopic enrichment and structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.