Description

n-(2-Methyl-D3-Benzoyl-D4)Glycine is a high-purity, isotopically labeled derivative of a key benzoyl glycine structure, specifically designed for advanced analytical and research applications. This compound matters because it provides the critical internal standard or tracer needed for precise quantification and metabolic pathway elucidation in complex biological matrices using techniques like LC-MS/MS. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and stable isotope labeling research.

Application

• Internal Standard for LC-MS/MS Quantification: Serves as a stable, non-interfering reference compound for the accurate bioanalysis of drugs and metabolites in plasma, serum, and tissue samples.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the metabolic fate, clearance pathways, and pharmacokinetic profiles of pharmaceutical candidates.
• Biomarker Research: Enables precise measurement of specific glycine-conjugated metabolites in clinical and preclinical studies.
• Stable Isotope Labeling: Acts as a building block or reference material in the synthesis of more complex isotopically labeled compounds for research.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Reference Standard Production: Used to calibrate systems and verify the purity and identity of unlabeled reference standards.

Basic Information

Product Name	n-(2-Methyl-D3-Benzoyl-D4)Glycine
CAS No.	1216430-90-8
Molecular Formula	C10H4D7NO3
Molecular Weight	~198.23 g/mol (for deuterated form)
Synonyms	2-Methyl-D3-benzoyl-D4-glycine; N-(2-Methyl-d3-benzoyl-d4)glycine; Deuterated Hippuric Acid Derivative; (2-Methyl-d3-benzoyl-d4)aminoacetic Acid; Isotopically Labeled Benzoylglycine; Hippuric Acid-d7 Derivative; [D7]-2-Methylhippuric Acid; Glycine, N-[(2-methyl-d3-phenyl-d4)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-(2-Methyl-D3-Benzoyl-D4)Glycine is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., D7 %), chemical assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.