Description

4-Hydroxy Alverine-D5 is a deuterated isotopologue of the primary metabolite of the antispasmodic agent alverine citrate. This compound is a critical reference standard and analytical tool for pharmaceutical research and development. It is primarily used by researchers and quality control laboratories in the pharmaceutical industry for method development, validation, and bioanalytical studies. The deuterium-labeled structure provides an essential internal standard for precise quantification via mass spectrometry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of alverine metabolites in complex matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS analysis to study the absorption, distribution, metabolism, and excretion (ADME) of alverine.
• Bioanalytical Method Development: Essential for developing and validating highly sensitive and specific analytical methods for clinical and preclinical studies.
• Impurity Profiling and Characterization: Aids in the identification and control of process-related impurities and degradation products in active pharmaceutical ingredient (API) manufacturing.
• Clinical Research: Supports pharmacokinetic and bioequivalence studies by enabling accurate measurement of metabolite concentrations in biological fluids.
• Quality Assurance/Quality Control (QA/QC): Ensures the accuracy and reliability of analytical results in pharmaceutical quality control laboratories.

Basic Information

Product Name	4-Hydroxy Alverine-D5
CAS No.	1216415-67-6
Molecular Formula	C20H22D5NO2
Molecular Weight	Contact for details
Synonyms	Alverine D5 Metabolite; N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine-3,3,4,4,5,5-d5 4-ol; 4-Hydroxy Alverine (phenyl-d5); 1-Propanamine, N-ethyl-3-phenyl-N-(3-phenylpropyl)-, 4-hydroxy- (phenyl-d5); Deuterated 4-Hydroxy Alverine; Alverine-d5 Hydroxy Metabolite; Alverine Metabolite M1-D5
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Alverine-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical and isotopic purity suitable for use as a reference standard. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.