Description

4-Benzylpiperazine-1-Carboxylic Acid-D8 tert-Butyl Ester CAS NO 1216387-74-4 is a deuterated derivative of a key piperazine-based building block, where eight hydrogen atoms are replaced with deuterium, significantly enhancing its utility in advanced research. This isotopic labeling is critical for creating internal standards in mass spectrometry, improving the accuracy and reliability of quantitative analytical methods in drug metabolism and pharmacokinetic (DMPK) studies. It is an essential intermediate for pharmaceutical chemists and analytical scientists working in drug discovery, development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of its non-deuterated counterpart and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Pharmaceutical Intermediate: Acts as a deuterated building block in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for clinical research.
• Forensic and Clinical Toxicology: Enables accurate detection and measurement of specific drugs or their metabolites in forensic and diagnostic testing.
• Biochemical Research: Employed in mechanistic studies to trace biochemical pathways and understand enzyme kinetics using deuterium isotope effects.
• Quality Control and Method Development: Essential for developing and validating robust analytical methods in GLP/GMP-compliant laboratories.

Basic Information

Item	Detail
Product Name	4-Benzylpiperazine-1-Carboxylic Acid-D8 tert-Butyl Ester
CAS No.	1216387-74-4
Molecular Formula	C16D8H16N2O2
Molecular Weight	280.39 g/mol
Synonyms	tert-Butyl 4-benzylpiperazine-1-carboxylate-d8; 1-Boc-4-benzylpiperazine-d8; 4-Benzyl-1-(tert-butoxycarbonyl)piperazine-d8; 1-(tert-Butoxycarbonyl)-4-benzylpiperazine-d8; BOC-4-Benzylpiperazine-d8; N-Boc-N'-benzylpiperazine-d8; Piperazine-1-carboxylic acid, 4-benzyl-, 1,1-dimethylethyl ester-d8; 1216387-74-4
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality protocols to ensure high isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D-content), chemical purity, and identity confirmation via spectroscopic methods. Our quality systems support compliance with the standards required for research, diagnostic, and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.