Description

6-Chloro-2,3-Dihydro-1H-Isoquinolin-4-One is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core isoquinolinone scaffold, functionalized with a reactive chlorine atom, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Organic Synthesis Building Block: The reactive chloro substituent enables further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating diverse chemical libraries.
• Material Science Research: Investigated as a monomer or precursor for constructing specialized polymers and organic electronic materials.
• Academic & Contract Research: Essential for medicinal chemistry programs and methodological studies in universities and CROs (Contract Research Organizations).

Basic Information

Product Name	6-Chloro-2,3-Dihydro-1H-Isoquinolin-4-One
CAS No.	1215929-51-3
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	6-Chloro-1,2,3,4-tetrahydroisoquinolin-4-one; 6-Chloro-3,4-dihydro-1H-isoquinolin-4-one; 6-Chloro-2,3-dihydro-4(1H)-isoquinolinone; 4(1H)-Isoquinolinone, 6-chloro-2,3-dihydro-; 6-Chloro-1,2,3,4-tetrahydro-4-isoquinolinone
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,3-Dihydro-1H-Isoquinolin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.