Description

Physcion-D3 is a deuterated analog of the naturally occurring anthraquinone derivative, Physcion, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and natural product research sectors who require precise quantification of Physcion and its metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of Physcion in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for Physcion and related compounds in preclinical and clinical research.
• Bioanalytical Method Development & Validation: A key component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Natural Product & Herbal Medicine Analysis: Used to quantify Physcion levels in plant extracts, herbal supplements, and traditional medicine formulations for quality control and standardization.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques to minimize matrix effects and improve analytical precision.
• Biomarker Research: Facilitates the reliable measurement of Physcion as a potential biomarker in various physiological or pathological studies.

Basic Information

Product Name	Physcion-D3
CAS No.	1215751-27-1
Molecular Formula	C16H9D3O5
Molecular Weight	287.29 g/mol
Synonyms	1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone-D3; 4,5,7-Trihydroxy-2-methylanthraquinone-D3; Parietin-D3; Rheochrysidin-D3; Emodin 3-methyl ether-D3; NSC 407303-D3; [2H3]-Physcion
EINECS	Contact for details

Quality Control

Every batch of Physcion-D3 is manufactured and analyzed under strict quality protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Our products undergo rigorous quality testing, including comprehensive spectroscopic analysis (NMR, MS) and chromatographic purity checks (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for isotopic enrichment, chemical purity, and identity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.