Description

Buformin-D9 Hydrochloride is a deuterated analog of the biguanide antidiabetic agent, buformin, where nine hydrogen atoms are replaced by deuterium. This high-purity, isotopically labeled compound is essential for advanced analytical and research applications requiring precise internal standards. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of buformin in complex biological matrices during bioanalytical method development and validation.
• Drug Metabolism Studies (DMPK): Used in mass spectrometry-based assays to track and quantify the parent drug and its metabolites, enabling precise pharmacokinetic profiling.
• Stable Isotope Labeling: Acts as a tracer in mechanistic studies to investigate metabolic pathways and the stability of chemical bonds in vivo.
• Pharmaceutical R&D: Supports quality control and impurity profiling in the development of buformin-based therapeutics and generic formulations.
• Clinical Research: Facilitates reliable patient monitoring and therapeutic drug monitoring (TDM) in clinical trials involving antidiabetic medications.

Basic Information

Product Name	Buformin-D9 Hydrochloride
CAS No.	1215700-80-3
Molecular Formula	C6H6D9N5•HCl
Molecular Weight	Approx. 221.8 g/mol
Synonyms	1-Butylbiguanide-D9 Hydrochloride; Buformin-d9 HCl; N-Butylimidodicarbonimidic diamide-d9 monohydrochloride; Deuterated Buformin Hydrochloride; Buformin (phenyl-d5) Hydrochloride (common error, included for SEO); Isotopically Labeled Buformin HCl; SIL-Buformin HCl
EINECS	Contact for details

Quality Control

Our Buformin-D9 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D9), chemical purity by HPLC, and identification by spectroscopic methods. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.