Description

4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]-n-[3-[4-(Trideuteriomethyl)Imidazol-1-Yl]-5-(Trifluoromethyl)Phenyl]Benzamide is a high-value, deuterated small molecule compound designed for advanced research and development. This compound is critical for pharmaceutical discovery, particularly in the development of targeted kinase inhibitors where its deuterated moiety can significantly influence metabolic stability and pharmacokinetic profiles. It serves as a key intermediate or reference standard for researchers in medicinal chemistry, process development, and analytical laboratories within the global life sciences sector.

Application

• Pharmaceutical R&D Intermediate: A crucial building block in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Deuterated Drug Discovery: Used to study the deuterium isotope effect (DIE) to improve metabolic stability and reduce toxicity of lead drug candidates.
• Reference Standard: Serves as a certified analytical standard for method development, validation, and quality control in API manufacturing.
• Biochemical Assay Development: Employed as a ligand or probe in high-throughput screening (HTS) and binding studies to identify new therapeutic targets.
• Process Chemistry: Used in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).
• Metabolite Identification Studies: Acts as a stable isotope-labeled internal standard in LC-MS/MS analysis for accurate quantification and metabolite profiling.

Basic Information

Product Name	4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]-n-[3-[4-(Trideuteriomethyl)Imidazol-1-Yl]-5-(Trifluoromethyl)Phenyl]Benzamide
CAS No.	1215678-43-5
Molecular Formula	C33H24D3F3N7O
Molecular Weight	597.62 g/mol
Synonyms	4-Methyl-3-[(4-(pyridin-3-yl)pyrimidin-2-yl)amino]-N-[3-[4-(trideuteriomethyl)-1H-imidazol-1-yl]-5-(trifluoromethyl)phenyl]benzamide; Deuterated Kinase Inhibitor Intermediate; 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-N-(3-(4-(trideuteriomethyl)-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide; Benzamide, 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[3-[4-(trideuteriomethyl)-1H-imidazol-1-yl]-5-(trifluoromethyl)phenyl]-; CAS 1215678-43-5
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]-n-[3-[4-(Trideuteriomethyl)Imidazol-1-Yl]-5-(Trifluoromethyl)Phenyl]Benzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as NMR (1H, 13C), HPLC, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.