Description

S-Methyl-D3-Thioacetaminophen is a deuterated isotopologue of a key thioacetaminophen derivative, specifically designed for advanced research and analytical applications. This compound is valued for its use as a stable isotope-labeled internal standard in quantitative mass spectrometry, providing superior accuracy and reliability in trace analysis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the precise quantification of S-methyl thioacetaminophen and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug disposition, absorption, and excretion pathways in preclinical and clinical research.
• Biomarker Research and Validation: Used in the development and validation of highly sensitive analytical assays for specific metabolic biomarkers.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during drug development and quality control.
• Reference Material for Certified Standards: Acts as a high-purity building block for the synthesis of certified reference materials (CRMs) used in regulated laboratories.

Basic Information

Product Name	S-Methyl-D3-Thioacetaminophen
CAS No.	1215669-56-9
Molecular Formula	C9H8D3NOS
Molecular Weight	182.27 g/mol
Synonyms	N-(4-Hydroxyphenyl)-S-methyl-D3-thioacetamide; Deuterated S-Methyl Thioacetaminophen; S-Methyl-D3-thioacetaminophen-d3; 4'-Hydroxy-S-methyl-D3-thioacetanilide; Acetaminophen S-Methyl-D3 Thioether; [Methyl-d3]thioacetaminophen; APAP S-Methyl-D3 Thioether; Internal Standard for Thioacetaminophen Metabolite
EINECS	Contact for details

Quality Control

Every batch of S-Methyl-D3-Thioacetaminophen is manufactured and tested under strict quality management systems to ensure the highest isotopic and chemical purity required for analytical applications. Our quality control protocols include comprehensive characterization by NMR, HPLC, and mass spectrometry to confirm structure, isotopic enrichment (D3, min. 99 atom % D), and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 99 atom % D (D3)
Chemical Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.