Description

Nafronyl-D4 CAS NO 1215649-28-7 is a deuterated isotopologue of the vasodilator Nafronyl, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for high-precision analytical and pharmacokinetic studies, serving as a critical internal standard in mass spectrometry. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and bioanalytical method development.

Application

• Internal standard for the quantitative bioanalysis of Nafronyl in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Metabolite identification and pharmacokinetic (PK) studies in drug discovery and development.
• Use in clinical research for accurate quantification of drug levels in patient samples.
• Stable isotope dilution analysis to ensure method accuracy and precision in regulatory submissions.
• Research into the metabolic pathways and clearance mechanisms of vasoactive pharmaceutical agents.
• Quality control and method validation in analytical laboratories following GLP guidelines.

Basic Information

Product Name	Nafronyl-D4
CAS No.	1215649-28-7
Molecular Formula	C24H29D4NO3
Molecular Weight	~ 395.55 g/mol
Synonyms	Nafronyl-d4; Nafronyl (tetradeuterated); 2-(Diethylamino)ethyl 3-methyl-2-[(tetradeuterio(2-naphthyl)methyl)]-1-oxo-2,3-dihydro-1H-isoindole-5-carboxylate; Nafridrofuryl-d4; LS-2616-d4; Naftidrofuryl-d4; Dusodril-d4; Praxilene-d4
EINECS	Contact for details

Quality Control

Our Nafronyl-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment, and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic nature, the material should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.