Description

Tolmetin-D3 Ethyl Ester is a high-purity, stable isotope-labeled analog of Tolmetin, a non-steroidal anti-inflammatory drug (NSAID). This deuterated compound is specifically engineered for use as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers focused on drug development and therapeutic monitoring.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in LC-MS/MS and GC-MS assays for the quantification of Tolmetin in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Pharmaceutical Quality Control: Supports method development and validation for the analysis of Tolmetin in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Clinical Toxicology: Used in confirmatory testing and accurate measurement of Tolmetin levels for therapeutic drug monitoring or forensic investigations.
• Stable Isotope Labeling Studies: Facilitates research into metabolic pathways and the differentiation between endogenous and exogenous compounds.

Basic Information

Product Name	Tolmetin-D3 Ethyl Ester
CAS No.	1215579-60-4
Molecular Formula	C17H16D3NO4
Molecular Weight	~ 298.34 g/mol
Synonyms	1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid ethyl ester-d3; Tolmetin Ethyl Ester-d3; Deuterated Tolmetin Ethyl Ester; [2H3]-Tolmetin Ethyl Ester; Ethyl 1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetate-d3; Tolmetin-d3 Ethyl Ester; Internal Standard for Tolmetin
EINECS	Contact for details

Quality Control

Our Tolmetin-D3 Ethyl Ester is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to cGMP principles for the production of reference standards, supporting your compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.