Description

Celiprolol-D9 Hydrochloride is a high-purity, isotopically labeled internal standard essential for precise quantitative analysis in pharmaceutical research and development. Its primary value lies in enabling accurate and reliable bioanalytical measurements, particularly in pharmacokinetic and metabolism studies, by correcting for variations during mass spectrometric analysis. This compound is critically needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development and quality control of cardiovascular drugs.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of Celiprolol in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical trials.
• Metabolite Identification & Profiling: Assists in the identification and quantification of drug metabolites using high-resolution mass spectrometry.
• Bioanalytical Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods compliant with FDA and ICH guidelines.
• Drug Impurity Testing: Supports stability-indicating methods to monitor the purity and stability of the active pharmaceutical ingredient (API).
• Clinical Research: Facilitates therapeutic drug monitoring and bioequivalence studies for generic drug development.

Basic Information

Product Name	Celiprolol-D9 Hydrochloride
CAS No.	1215535-20-8
Molecular Formula	C20H24D9N3O4•HCl
Molecular Weight	~ 424.0 g/mol
Synonyms	Deuterated Celiprolol HCl; Celiprolol (phenyl-D5, ethyl-D4) Hydrochloride; 3-[3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethyl(phenyl-D5, ethyl-D4)urea Hydrochloride; (±)-Celiprolol-D9 Hydrochloride; Celiprolol D9 HCl; Celiprolol-d9 HCl; Selectol-d9 HCl
EINECS	Contact for details

Quality Control

Our Celiprolol-D9 Hydrochloride is manufactured under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and other critical parameters. We adhere to relevant industry standards for reference materials to support GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.