Description

n-Methyl-4-Aminobutyric Acid-D3 is a deuterated analog of the neurotransmitter precursor 4-aminobutyric acid (GABA), specifically labeled with three deuterium atoms on the methyl group. This stable isotope-labeled compound is essential for advanced analytical research, providing an internal standard for precise quantification in mass spectrometry. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for drug metabolism studies, pharmacokinetic research, and the development of sensitive bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of GABA analogs and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of new pharmaceutical candidates targeting the GABAergic system.
• Biomarker Research: Enables precise measurement of endogenous GABA levels in neurological and metabolic disorder research, aiding in the discovery and validation of clinical biomarkers.
• Synthetic Intermediate: Acts as a labeled building block for the synthesis of more complex deuterated molecules for use in various research and development programs.
• Quality Control in Manufacturing: Employed in the analytical laboratories of fine chemical and active pharmaceutical ingredient (API) manufacturers to ensure batch consistency and purity.

Basic Information

Item	Detail
Product Name	n-Methyl-4-Aminobutyric Acid-D3
CAS No.	1215511-11-7
Molecular Formula	C5H8D3NO2
Molecular Weight	118.16 g/mol
Synonyms	4-(Methyl-d3-amino)butyric Acid; (3-Aminopropyl)methyl-d3-amine Carboxylic Acid; GABA Methyl-d3 Ester; 4-(N-Methyl-d3-amino)butanoic Acid; Deuterated N-Methyl-GABA; N-Methyl-γ-aminobutyric Acid-d3; Methyl-d3-GABA; 1215511-11-7
EINECS	Contact for details

Quality Control

Every batch of n-Methyl-4-Aminobutyric Acid-D3 is produced and analyzed under strict quality management protocols. We ensure high chemical and isotopic purity through advanced analytical techniques, including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity, isotopic enrichment, and residual solvents. Our quality system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.