Description

(+/-)-Metanephrine-D3 Hcl (n-Methyl-D3) CAS NO 1215507-88-2 is a deuterium-labeled internal standard of the catecholamine metabolite metanephrine, specifically labeled on the N-methyl group. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly liquid chromatography-mass spectrometry (LC-MS/MS). It is a critical reagent for clinical diagnostics, pharmaceutical research, and forensic toxicology laboratories requiring precise measurement of metanephrine and normetanephrine levels in biological matrices.

Application

• LC-MS/MS Internal Standard for the quantitative analysis of metanephrine in plasma, serum, and urine.
• Clinical Diagnostics for the accurate diagnosis and monitoring of pheochromocytoma and paraganglioma.
• Biomarker Research in studies related to catecholamine metabolism, hypertension, and stress response.
• Pharmaceutical Development for pharmacokinetic (PK) and pharmacodynamic (PD) studies of drugs affecting the sympathetic nervous system.
• Forensic Toxicology in the definitive identification and quantification of catecholamine metabolites.
• Method Development & Validation to establish robust, high-sensitivity analytical protocols in compliance with GLP/GCP guidelines.
• Quality Control in the production of in-vitro diagnostic (IVD) kits for endocrine testing.

Basic Information

Product Name	(+/-)-Metanephrine-D3 Hcl (n-Methyl-D3)
CAS No.	1215507-88-2
Molecular Formula	C10H12D3ClNO3
Molecular Weight	229.72 g/mol
Synonyms	DL-Metanephrine-D3 hydrochloride; 3-Methoxy-DL-adrenaline-D3 hydrochloride; 4-[1-Hydroxy-2-[(methyl-d3)amino]ethyl]-2-methoxyphenol hydrochloride; Metanephrine (N-methyl-D3) hydrochloride; (±)-Metanephrine-D3 HCl; Metanephrine-d3 HCl; Internal Standard for Metanephrine LC-MS
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Metanephrine-D3 HCl is manufactured and tested under strict quality systems. We provide comprehensive analytical data to support its use as a certified reference material, including confirmation of isotopic purity (D-enrichment) and chemical purity. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from NMR, HPLC, and MS analysis. Our quality commitment ensures consistency and reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D (N-methyl-D3)
Chemical Purity	≥ 95.0% (by HPLC)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.