Description

Na€-Desmethyl Amonafide-D5 is a deuterium-labeled internal standard critical for precise quantitative analysis in bioanalytical research. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and biomarker discovery.

Application

• Primary use as an internal standard for the quantification of Amonafide and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to ensure data integrity and regulatory compliance.
• Enables accurate metabolite profiling and drug metabolism studies (DMPK) in preclinical and clinical research.
• Supports method development and validation in regulated bioanalytical laboratories following FDA/EMA guidelines.
• Used in research investigating the mechanism of action and stability of topoisomerase II inhibitors.

Basic Information

Product Name	Na€-Desmethyl Amononafide-D5
CAS No.	1215400-25-1
Molecular Formula	C16H13D5N4O2
Molecular Weight	291.36 g/mol
Synonyms	1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)-D5; Deuterated Desmethyl Amonafide; Amonafide D5 Internal Standard; 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione-d5; N-Desmethylamonafide-d5; [D5]-N-Desmethyl Amonafide
EINECS	Contact for details

Quality Control

Every batch of Na€-Desmethyl Amonafide-D5 is manufactured and tested under strict quality management systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific purity, chemical purity, isotopic purity (D-enrichment), and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chemical Purity (HPLC)	≥95.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.