Description

tert-Butyl 5-(Hydroxymethyl)-4-Methylthiazol-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its functionalized thiazole core. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily sought by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for its role in constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other small-molecule drug candidates.
• Bioconjugation & Prodrug Development: The hydroxymethyl group provides a versatile handle for conjugation, enabling the creation of prodrugs or antibody-drug conjugates (ADCs).
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis: Employed in contract research and manufacturing (CRAM) for the custom synthesis of specialized compounds for clients.

Basic Information

Product Name	tert-Butyl 5-(Hydroxymethyl)-4-Methylthiazol-2-Ylcarbamate
CAS No.	1215121-73-5
Molecular Formula	C10H16N2O3S
Molecular Weight	244.31 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-4-methylthiazole-5-methanol; 5-(Hydroxymethyl)-4-methyl-2-thiazolylcarbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl N-[5-(hydroxymethyl)-4-methyl-1,3-thiazol-2-yl]carbamate; BOC-Protected 5-Hydroxymethyl-4-methylthiazol-2-amine; 2-((BOC)amino)-4-methyl-5-thiazolemethanol
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Hydroxymethyl)-4-Methylthiazol-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.