Description

Donepezil-D7 CAS NO 1215071-00-3 is a deuterated internal standard of the acetylcholinesterase inhibitor donepezil, where seven hydrogen atoms are replaced with the stable isotope deuterium. This isotopic labeling is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmacokinetic and metabolic studies. It is an essential analytical tool for pharmaceutical research and development, quality control laboratories, and clinical testing facilities focused on Alzheimer's disease therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of donepezil concentrations.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in biological matrices like plasma, serum, and tissue homogenates.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of donepezil metabolites during drug metabolism and pharmacodynamics (DMPK) research.
• Pharmaceutical Quality Control (QC): Used in the validation of analytical methods and routine QC testing to ensure the potency and purity of donepezil active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies investigating drug efficacy, safety, and optimal dosing regimens in patient populations.
• Forensic and Toxicology Analysis: Facilitates the accurate quantification of donepezil in forensic investigations or cases of suspected overdose.

Basic Information

Product Name	Donepezil-D7
CAS No.	1215071-00-3
Molecular Formula	C24H18D7NO3
Molecular Weight	388.49 g/mol (for C24H18D7NO3)
Synonyms	Donepezil-d7; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one-d7; 1-Benzyl-4-[(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl]piperidine-d7; Aricept-d7 (deuterated); E2020-d7; (±)-Donepezil-d7; (RS)-Donepezil-d7; Deuterated Donepezil Internal Standard
EINECS	Contact for details

Quality Control

Our deuterated standards, including Donepezil-D7, are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is analyzed by advanced spectroscopic and chromatographic techniques (NMR, HPLC, LC-MS) to confirm identity, isotopic enrichment (≥98% D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and analytical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.