Description

6-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-n-(Tetrahydro-2H-Pyran-4-Yl)-1H-Indazol-3-Amine CAS NO 1214900-68-1 is a high-purity, advanced pharmaceutical intermediate featuring a complex indazole core with dual tetrahydropyran (THP) protecting groups. This compound is specifically engineered for use in sophisticated medicinal chemistry and drug discovery programs, offering a critical building block for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies developing targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Kinase Inhibitor Development: Used in the construction of potential kinase inhibitors due to the privileged indazole structure.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological processes and protein function.
• Custom Synthesis: A starting material for the custom synthesis of more complex, target-specific molecules for preclinical research.
• Process Chemistry: Used in route scouting and scale-up studies for the development of efficient synthetic pathways to active pharmaceutical ingredients (APIs).

Basic Information

Product Name	6-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-n-(Tetrahydro-2H-Pyran-4-Yl)-1H-Indazol-3-Amine
CAS No.	1214900-68-1
Molecular Formula	C17H22BrN3O2
Molecular Weight	380.28 g/mol
Synonyms	6-Bromo-1-(tetrahydro-2H-pyran-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazol-3-amine; 6-Bromo-1-(THP-2-yl)-N-(THP-4-yl)-1H-indazol-3-amine; 1H-Indazol-3-amine, 6-bromo-1-(tetrahydro-2H-pyran-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-; 1214900-68-1; 6-Br-1-THP-N-THP-1H-indazol-3-amine; 3-Amino-6-bromo-1-(2-tetrahydropyranyl)-N-(4-tetrahydropyranyl)indazole
EINECS	Contact for details

Quality Control

Our 6-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-n-(Tetrahydro-2H-Pyran-4-Yl)-1H-Indazol-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.