Description

tert-Butyl 6-Bromo-1-Oxo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel drug candidates, especially in therapeutic areas targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bioactive isoquinoline derivatives and potential drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors or receptor modulators for biological pathway analysis.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs).
• Academic Research: Valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.
• Agrochemical Synthesis: Potential intermediate for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	tert-Butyl 6-Bromo-1-Oxo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1214900-33-0
Molecular Formula	C₁₄H₁₆BrNO₃
Molecular Weight	326.19 g/mol
Synonyms	6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-6-bromo-1,2,3,4-tetrahydroisoquinolin-1-one; tert-Butyl 6-bromo-1-oxo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 6-Bromo-2-Boc-1,2,3,4-tetrahydroisoquinolin-1-one; 6-Bromo-1-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; Boc-6-Bromo-1-oxo-THIQ; 1214900-33-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-1-Oxo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.