Description

1H-Indazol-6-Amine, 3-Ethyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group. This compound is specifically designed for use in complex organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs). It is essential for research and manufacturing chemists in the pharmaceutical and biotechnology sectors who require reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways.
• Organic Synthesis Reagent: Used in advanced organic reactions, including cross-coupling and functional group transformations, due to its protected amine and indazole core.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential new chemical entities (NCEs).
• Bioconjugation & Probe Synthesis: The reactive amine, once deprotected, can be utilized for labeling and conjugation applications in chemical biology.

Basic Information

Product Name	1H-Indazol-6-Amine, 3-Ethyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	1214900-20-5
Molecular Formula	C15H25N3OSi
Molecular Weight	291.47 g/mol
Synonyms	3-Ethyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-amine; 3-Ethyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-6-amine; 6-Amino-3-ethyl-1-((2-(trimethylsilyl)ethoxy)methyl)indazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-3-ethyl-1H-indazol-6-amine; SEM-Protected 3-Ethyl-6-aminoindazole; 3-Ethyl-6-amino-1-SEM-indazole
EINECS	Contact for details

Quality Control

Our 1H-Indazol-6-Amine, 3-Ethyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.