Description

3-Methyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Indazol-6-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core protected by a trimethylsilylethoxymethyl (SEM) group. This compound is critical for its role as a versatile building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted drug candidates, especially those with indazole-based scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with potential therapeutic value.
• Kinase Inhibitor Development: Serves as a core structural component in the research and production of protein kinase inhibitors for oncology and inflammatory diseases.
• Organic Synthesis Building Block: The SEM-protected amine functionality allows for selective reactions, making it valuable for constructing complex heterocyclic systems in organic synthesis.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects and process development for clinical trial materials.

Basic Information

Product Name	3-Methyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Indazol-6-Amine
CAS No.	1214900-04-5
Molecular Formula	C15H25N3OSi
Molecular Weight	291.47 g/mol
Synonyms	6-Amino-3-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole; 1H-Indazol-6-amine, 3-methyl-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 3-Methyl-1-SEM-1H-indazol-6-amine; 3-Methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-amine; 6-Amino-3-methyl-1-SEM-indazole; 1214900-04-5; SEM-protected 6-amino-3-methylindazole
EINECS	Contact for details

Quality Control

Our 3-Methyl-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Indazol-6-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.