Description

27-o-Acetyl-Withaferin A is a semi-synthetic, acetylated derivative of the bioactive steroidal lactone Withaferin A, a key constituent of the medicinal plant Withania somnifera (Ashwagandha). This modification enhances its lipophilicity and can significantly alter its biological activity profile, making it a critical compound for advanced pharmacological research and development. It is primarily utilized by research scientists and product developers in the pharmaceutical, nutraceutical, and cosmeceutical industries for investigating novel therapeutic pathways and developing high-value bioactive ingredients.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate for studying anti-inflammatory, anti-cancer, and neuroprotective mechanisms.
• Nutraceutical Formulation: Used in the development of advanced herbal extracts and dietary supplements targeting stress, immunity, and cognitive health.
• Cosmeceutical Actives: Incorporated into skincare formulations for its potential anti-aging and skin-soothing properties derived from its parent compound.
• Biochemical Research: Employed as a precise molecular tool in cell biology and signal transduction studies to probe specific biological pathways.
• Analytical Standard: Essential as a high-purity certified reference material (CRM) for quality control and quantification in analytical laboratories.

Basic Information

Product Name	27-o-Acetyl-Withaferin A
CAS No.	1214886-35-7
Molecular Formula	C30H38O7
Molecular Weight	510.62 g/mol
Synonyms	27-O-Acetylwithaferin A; Withaferin A 27-acetate; (22R)-27-(Acetyloxy)-1,6-dioxo-5,6,14,15,16,17-hexadehydro-4,5-seco-5,27-cyclowitha-2,24-dienolide; 4,5-Seco-5,27-cyclowitha-2,24-dienolide, 27-(acetyloxy)-1,6-dioxo-5,6,14,15,16,17-hexadehydro-, (22R)-; Acetyl Withaferin A
EINECS	Contact for details

Quality Control

Our 27-o-Acetyl-Withaferin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) documenting purity, impurities, and full characterization data is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.