Description

2-Bromo-3-(Trifluoromethyl)Benzyl Bromide is a versatile and highly functionalized benzyl bromide derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of both bromine atoms and the electron-withdrawing trifluoromethyl group, enabling selective cross-coupling and substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl motifs known to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the benzyl bromide moiety facilitates the introduction of specific side chains.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers requiring fluorinated aromatic units.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings due to the reactive benzyl bromide and aryl bromide functionalities.
• Custom Synthesis & R&D: A valuable reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	2-Bromo-3-(Trifluoromethyl)Benzyl Bromide
CAS No.	1214372-35-6
Molecular Formula	C8H5Br2F3
Molecular Weight	317.93 g/mol
Synonyms	alpha,2-Dibromo-3-(trifluoromethyl)toluene; 1-(Bromomethyl)-2-bromo-3-(trifluoromethyl)benzene; (2-Bromo-3-(trifluoromethyl)phenyl)methyl bromide; 2-Bromo-3-(trifluoromethyl)benzyl bromide; 2-Bromo-α-(bromomethyl)-3-(trifluoromethyl)toluene; Benzene, 1-(bromomethyl)-2-bromo-3-(trifluoromethyl)-; 3-Trifluoromethyl-2-bromobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature and reactive bromine groups, it is recommended to handle under an inert atmosphere for extended storage and use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.