Description

3-Bromo-5-(Trifluoromethyl)Pyridine-2-Thiol is a high-value, multi-functional heterocyclic building block characterized by its reactive bromine and thiol groups, as well as the electron-withdrawing trifluoromethyl substituent. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis due to the versatile thiol and halogen functionalities.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for constructing molecular probes and bioconjugation linkers, leveraging the thiol group for selective attachment to biomolecules.

Basic Information

Product Name	3-Bromo-5-(Trifluoromethyl)Pyridine-2-Thiol
CAS No.	1214372-31-2
Molecular Formula	C6H3BrF3NS
Molecular Weight	258.06 g/mol
Synonyms	2-Mercapto-3-bromo-5-(trifluoromethyl)pyridine; 3-Bromo-5-(trifluoromethyl)-2-pyridinethiol; 3-Bromo-5-(trifluoromethyl)pyridine-2-thione (tautomer); 2-Pyridinethiol, 3-bromo-5-(trifluoromethyl)-; 3-Bromo-5-trifluoromethylpyridine-2-thiol; 3-Bromo-5-trifluoromethyl-2-mercaptopyridine; 1214372-31-2
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Trifluoromethyl)Pyridine-2-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to prevent oxidation of the thiol group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.