Description

3-(2-Chloropyrimidin-4-Yl)-7-Methyl-1H-Indole (Wxc04916) is a high-purity, advanced pharmaceutical intermediate featuring a fused indole-pyrimidine heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in oncology and anti-inflammatory drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitors for targeted cancer therapies.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization of compounds targeting specific enzymatic pathways.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study protein function and intracellular signaling mechanisms.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of active pharmaceutical ingredients (APIs) and other high-value fine chemicals.
• Academic Research: Utilized in university and institutional labs for investigating new heterocyclic chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	3-(2-Chloropyrimidin-4-Yl)-7-Methyl-1H-Indole (Wxc04916)
CAS No.	1214264-51-3
Molecular Formula	C₁₃H₁₀ClN₃
Molecular Weight	243.69 g/mol
Synonyms	7-Methyl-3-(2-chloropyrimidin-4-yl)-1H-indole; 3-(2-Chloro-4-pyrimidinyl)-7-methyl-1H-indole; WXC-04916; Wxc04916; 1H-Indole, 3-(2-chloro-4-pyrimidinyl)-7-methyl-; 3-(2-Chloropyrimidin-4-yl)-7-methylindole
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Chloropyrimidin-4-Yl)-7-Methyl-1H-Indole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing to ensure compliance with exacting purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and MS is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.