Description

3-Amino-5-Fluoroindolin-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific indolinone scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors for oncology research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up processes for new chemical entities (NCEs).
• Biochemical Research: Employed as a tool compound in enzymatic assays and biological target validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	3-Amino-5-Fluoroindolin-2-One Hydrochloride
CAS No.	1214238-11-5
Molecular Formula	C8H8FN2O·HCl
Molecular Weight	202.62 g/mol (Free base: 166.16 g/mol)
Synonyms	5-Fluoro-3-aminoindolin-2-one hydrochloride; 3-Amino-5-fluoro-2-indolinone hydrochloride; 2-Indolinone, 3-amino-5-fluoro-, hydrochloride; 5-Fluoro-3-aminooxindole hydrochloride; 3-Amino-5-fluoro-1,3-dihydro-2H-indol-2-one hydrochloride; 1214238-11-5; AI3-71062
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Fluoroindolin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.