Description

3-Amino-5-Methyl-1,3-Dihydro-2H-Indol-2-One Hydrochloride is a high-purity, pharmaceutically relevant indole derivative, specifically a functionalized oxindole hydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis for drug discovery and development. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of novel bioactive molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with indole or oxindole core structures.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential therapeutic agents, including kinase inhibitors and receptor modulators.
• Chemical Biology Probes: Serves as a starting material for developing labeled compounds or probes used to study biological pathways and target engagement.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.

Basic Information

Item	Details
Product Name	3-Amino-5-Methyl-1,3-Dihydro-2H-Indol-2-One Hydrochloride
CAS No.	1214232-17-3
Molecular Formula	C9H11ClN2O
Molecular Weight	198.65 g/mol
Synonyms	3-Amino-5-methyl-2-oxindole hydrochloride; 5-Methyl-3-aminooxindole hydrochloride; 3-Amino-5-methylindolin-2-one hydrochloride; 2H-Indol-2-one, 3-amino-1,3-dihydro-5-methyl-, hydrochloride (1:1); 5-Methyl-3-amino-1,3-dihydro-2H-indol-2-one hydrochloride; 3-Amino-5-methyl-1H-indole-2,3-dione hydrochloride (tautomeric form); 5-Methylisatin-3-imine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Methyl-1,3-Dihydro-2H-Indol-2-One Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support development and commercial projects requiring material that meets ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container sealed under an inert atmosphere if possible after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.