Description

7-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, synthetically derived organic compound that serves as a critical chiral building block in advanced pharmaceutical research and development. Its value lies in its unique tetrahydroisoquinoline scaffold, which is a privileged structure found in numerous bioactive molecules, enabling the synthesis of complex drug candidates. This intermediate is essential for medicinal chemists and process development scientists working in the pharmaceutical and fine chemical industries, particularly for projects targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development of robust, scalable synthetic routes for potential drug candidates.
• Building Block for Bioactive Molecules: Integral for constructing complex molecules with potential activity in neurological, cardiovascular, and oncological pathways.
• Asymmetric Synthesis: Utilized in chiral pool synthesis or as a substrate for asymmetric transformations to introduce stereochemical complexity.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	7-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1214066-85-9
Molecular Formula	C₁₀H₁₀ClNO₂
Molecular Weight	211.65 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-7-chloroisoquinoline-1-carboxylic acid; (1S)-7-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (for enantiopure form); 7-Chloro-THIQ-1-COOH; 7-Cl-THIQ-1-COOH; 7-Chloro-1-carboxy-1,2,3,4-tetrahydroisoquinoline; 1-Carboxy-7-chloro-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.