Description

(R)-5,6,7,8-Tetrahydro-Isoquinolin-8-Ylamine CAS NO 1213648-37-3 is a high-purity chiral amine building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for applications in drug discovery, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce the (R)-configured amine functionality into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the development of new, stereochemically defined active ingredients for crop protection.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for scaling up bespoke synthetic routes.
• Peptidomimetics: Incorporated into the design of peptide-like compounds with enhanced metabolic stability and bioavailability.

Basic Information

Item	Details
Product Name	(R)-5,6,7,8-Tetrahydro-Isoquinolin-8-Ylamine
CAS No.	1213648-37-3
Molecular Formula	C9H12N2
Molecular Weight	148.21 g/mol
Synonyms	(R)-5,6,7,8-Tetrahydroisoquinolin-8-amine; (8R)-5,6,7,8-Tetrahydroisoquinolin-8-amine; (R)-8-Amino-5,6,7,8-tetrahydroisoquinoline; (R)-THIQ-8-amine; (R)-Tetrahydronorlaudanosoline; (R)-1,2,3,4-Tetrahydro-8-isoquinolinamine; (R)-8-Aminotetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (R)-5,6,7,8-Tetrahydro-Isoquinolin-8-Ylamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity by HPLC. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.