Description

5-((2R)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen is a high-value, chiral piperazine-thiophene hybrid compound, serving as a critical building block in modern pharmaceutical research and development. Its core value lies in providing a structurally unique scaffold that enables the synthesis of novel, targeted bioactive molecules. This advanced intermediate is essential for medicinal chemists and process development scientists working in the discovery and scale-up of new therapeutic agents, particularly within the central nervous system (CNS) and oncology spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a privileged scaffold in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• CNS Drug Discovery: Employed in the synthesis of potential therapeutics targeting neurological disorders, leveraging the piperazine moiety's common role in CNS pharmacology.
• Oncological Agent Development: Serves as a building block for novel kinase inhibitors and other targeted cancer therapies.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of complex drug molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research organizations for custom synthesis projects.

Basic Information

Product Name	5-((2R)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen
CAS No.	1213629-43-6
Molecular Formula	C9H12F3N3S
Molecular Weight	251.27 g/mol
Synonyms	(2R)-2-[5-(Trifluoromethyl)thiophen-2-yl]piperazine; 2-(Trifluoromethyl)-5-[(2R)-piperazin-2-yl]thiophene; (R)-2-(5-(Trifluoromethyl)thiophen-2-yl)piperazine; 5-[(2R)-Piperazin-2-yl]-2-(trifluoromethyl)thiophene; CAS 1213629-43-6
EINECS	Contact for details

Quality Control

Our 5-((2R)Piperazin-2-Yl)-2-(Trifluoromethyl)Thiophen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee reproducible results in your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain long-term stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.