Description

(2S)-2-Amino-2-(2-Bromo-5-Fluorophenyl)Ethan-1-Ol CAS NO 1213371-91-5 is a high-purity chiral amino alcohol building block of significant importance in modern pharmaceutical synthesis. Its value lies in its unique molecular structure, which incorporates both bromo and fluoro substituents on an aromatic ring, making it a critical intermediate for the development of targeted active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical and biotechnology industries who require sophisticated, fluorinated synthons for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) that require a fluorinated and brominated aromatic moiety.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in asymmetric catalytic reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of advanced pharmaceutical intermediates.

Basic Information

Product Name	(2S)-2-Amino-2-(2-Bromo-5-Fluorophenyl)Ethan-1-Ol
CAS No.	1213371-91-5
Molecular Formula	C8H9BrFNO
Molecular Weight	234.07 g/mol
Synonyms	(2S)-2-Amino-2-(2-bromo-5-fluorophenyl)ethanol; (S)-2-Amino-2-(2-bromo-5-fluorophenyl)ethan-1-ol; 2-Bromo-5-fluoro-D-phenylglycinol; (S)-2-(2-Bromo-5-fluorophenyl)-2-aminoethanol; 2-Amino-2-(2-bromo-5-fluorophenyl)ethanol (S-enantiomer); 1213371-91-5; (S)-2-(2-Bromo-5-fluorophenyl)glycinol
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-2-(2-Bromo-5-Fluorophenyl)Ethan-1-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet stringent customer specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.